The use of chemical pesticides in plant protection disturbs the natural balance and degrades the environment. In this way, the natural enemies of pests, namely their population, are removed from agricultural production areas. Consequently, in order to control a certain population of pests, permanent use of chemical pesticides is required. Over time, pests develop resistance to a particular chemical pesticide and for their effective control is required higher dose or the production and application of new types of chemical pesticides. On the contrary, application of biological plant protection measures does not have these negative consequences, apropos the stability and balance of the agroecosystem is maintained. Biological plant protection measures can be implemented in classical, augmentative and conservative ways. These biological measures include beneficial organisms that can be predators or parasitoids, depending on the type of their diet. They attack, infect or feed on pests and thus keep their population below the economic damage threshold. The most important species are found among mammals, birds, insects, mites and nematodes. Commercial production and application of these beneficial organisms in the form of macrobiological agents or biopesticides is carried out all over the world, and only in Europe there are some reputable manufacturers. Biopesticides are most commonly used in the form of bioinsecticides. The application of biopesticides is applied in all types of crops, but require larger amount of knowledge. Due to easier condition control, in practice, they are more often used in in protected areas than in outdoors. There is no production of such preparations in the Republic of Croatia, but they can be purchased from authorized representatives.