The teacher should possess certain competences in order to ensure quality upbringing and education for a student with difficulties. Cooperation with the educational rehabilitator and other teachers, as well as with parents, is essential in order to enable the student to make as much progress as possible. There are several types of disabilities and each of these disabilities requires appropriate adjustments and individualization. Each student with difficulties requires a different approach and the use of different work methods. It is important to include students with disabilities in all activities and not single them out. The goals of this research are to investigate whether students of teachers' colleges are ready to work with students with disabilities after completing their studies and whether they have acquired sufficient competences for work. The sample includes 82 teacher studies students in the Republic of Croatia. The results of the research show that students are not sufficiently prepared to work with students with disabilities and that new courses related to students with disabilities need to be introduced at the faculties. Likewise, they believe that they are not competent enough to work with students with disabilities. Most students want to go to additional education after completing their studies and are ready to cooperate with professional colleagues and parents.